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24was $2.2 updates big phish billion, or guitar tab spells out 37 cents a share, compared with $2.2billion, or 35 cents a share, in the year-ago quarter. But it has forecast revenue will fall 5 percent to 10percent year-on-year in the current quarter ending later thismonth and made plans to cut spending for the full fiscal yearby over $1 billion from its original budget. Cisco shares had closed down 84 cents or almost 5 percenton Nasdaq before Chambers made the comments. (Additional reporting by Ritsuko Ando in New York Editing by Carol Bishopric) Stocks.

TAINAN, Taiwan--(Business Wire)--NCKU Associate Professor Ying-Jan Wang from the Department of Environmental andOccupational Health of Medical College has led a research team to conduct aseries of experiments on mice for ascertaining that 5-OH-HxMF(5-hydroxy-3,6,7,8,3`,4`- hexamethoxyflavone), a kind of polymethoxyflavonesextracted from Citrus genus, has been efficacious in inflammation and neoplasia.This research achievement has been warranted for its publication in"Carcinogenesis," a prestigious academic journal with foci on cancer biology,molecular epidemiology, cancer prevention and carcinogenesis emil's phish . The research team, led by Professor Wang, has experimented on small mice modelto screen anti-cancer components in food as well as finding possible carcinogenscaused by environmental poisons, since 2003 bass tabs . Professor Wang has studied theeffect of 5-OH-HxMF on the expression of inductible nitric oxide synthase (iNOS)and prostaglandin-endoperoxide synthase 2 (COX-2, cyclooxygenase-2), both kindsof neoplasia-induced factor, on mouse skin to explore underlying molecularworking mechanisms trey anastasio band . Results inferred from small mice`s skin reaction to5-OH-HxMF, extracted from Citrus genus, shed light on an account for the basicmolecular mechanisms of iNOS and COX-2, which is known to play a pivotal role incolon tumorigenesis gin and juice . Polymethoxyflavones (PMFs), found exclusively in the Citrus genus, particularlyin the peel of sweet oranges (Citrus sinensis) and mandarin oranges (Citrusreticulate), have a broad spectrum of biological activities includinganti-carcinogenic, anti-inflammatory, and anti-tumor activities. The intake ofcitrus fruit has been suggested for prevention of the development of certainhuman cancers. It is also commonly recognized that cancer induction can beprevented by ingestion of certain food phytochemicals.

Flavonoids in citrusfruits and juices have been said to be one of the most prominentcancer-preventing agents . PMFs have higher permeability through the smallintestine and are readily absorbed into the human blood circulatory system you enjoy myself . The recent successful isolation of 5-hydroxy-3,6,7,8,3`,4`-hexamethoxyflavone(5-OH-HxMF) extracted from sweet orange peel and the reported biologicalactivities of other PMFs have stimulated Professor Wang to further studyanti-inflammatory and anti-tumor capabilities of polymethoxyflavones bouncing around the room . According to Professor Wang, it has been known that inflammation is causallylinked to carcinogenesis and acts as a driving force in premalignant andmalignant transformation of cells . The research team has tested theanti-inflammatory efficacy of 5-OH-HxMF in mouse skin, and investigated theinhibitory effect of 5-OH-HxMF on mouse skin tumor promotion using a two-stagecarcinogenesis model including tumor incidence, multiplicity, and volume. "Wefound that the topical application of 5-OH-HxMF can effectively inhibit thetranscriptional activation of iNOS and COX-2 mRNA and protein in mouse skinstimulated by carcinogens as well as to suppress the binding possibilities ofcarcinogenic substances with DNA," said Professor Wang. iNOS has been shown to be involved in COX-2 regulation, especially pivotal incolon tumorigenesis.